3D simulations of radiotracer uptake in deep nuclei of human brain
Identifieur interne : 004374 ( Main/Exploration ); précédent : 004373; suivant : 0043753D simulations of radiotracer uptake in deep nuclei of human brain
Auteurs : O. Rousset [Canada] ; Y. Ma [Canada] ; M. Kamber [Canada] ; A. C Evans [Canada]Source :
- Computerized Medical Imaging and Graphics [ 0895-6111 ] ; 1993.
Abstract
The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).
Url:
DOI: 10.1016/0895-6111(93)90031-H
Affiliations:
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Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Rousset, O" sort="Rousset, O" uniqKey="Rousset O" first="O" last="Rousset">O. Rousset</name></region><name sortKey="Evans, A C" sort="Evans, A C" uniqKey="Evans A" first="A. C" last="Evans">A. C Evans</name><name sortKey="Kamber, M" sort="Kamber, M" uniqKey="Kamber M" first="M" last="Kamber">M. Kamber</name><name sortKey="Ma, Y" sort="Ma, Y" uniqKey="Ma Y" first="Y" last="Ma">Y. Ma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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